Planning a trip to South Carolina ? With major metro areas such as Columbia and Charleston, along with top attractions including Brookgreen Gardens, Fort Sumter and Middleton Place; you are sure to have a unique and memorable experience. Take in all the great sights that South Carolina has to offer with a car hire from Enterprise Rent-A-Car. Choose from one of our popular airport locations or find the perfect car at a neighborhood branch. Search for a car hire location or browse the list below.