Drive down the Pacific Coast Highway on your road trip from San Diego to San Francisco and enjoy scenic views, unforgettable beaches and more.

This road trip itinerary covers all the things to see and do along the drive from San Francisco to San Diego on Highway 99.

Looking to get from San Diego to San Francisco using the fastest, most direct route? This is the road trip itinerary for you.

Rent a convertible and hit the road as you take this laid-back road trip from Los Angeles to San Diego. Enjoy the beautiful coastline and the incredible weather of Southern California.

Looking to go from Los Angeles to San Diego? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Take your time to explore this scenic stretch of the Pacific Coast Highway from San Francisco to Los Angeles.

Looking to go from Los Angeles to San Francisco? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Discover the beauty of the California coast on a road trip from Los Angeles to San Francisco via the Pacific Coast Highway.

Looking to go from Sacramento to Yosemite? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and enhanced vehicle cleaning procedures.

Drive from Sacramento to Lake Tahoe with Enterprise. Learn what to expect and tips and tricks for this popular road trip.

Drive from the sandy beaches of San Diego through national forests and desert flat lands on the way to the urban oasis, Las Vegas.

Make the drive from San Diego to Disneyland and see all the best stops along the way using this driving itinerary.

Explore the landscapes from sand dunes and sandy beaches to the urban oasis and national forests when driving from Las Vegas to San Diego.

Check out some of the top National & State Parks near San Diego. Rent a car from one of our neighborhood locations and hit the road!

Looking to go from San Francisco to Yosemite? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and enhanced vehicle cleaning procedures.

With stunning forests and breathtaking coastlines, enjoy the beauty and adventure found along Highway 101 with this road trip itinerary from San Francisco to Portland.

Go on a San Francisco to Seattle 3-day road trip with this comprehensive guide to two of the West Coast's most popular destinations.

Discover the Pacific Northwest through a road trip from Seattle to San Francisco.

If you are planning a San Francisco to Lake Tahoe road trip, look no further. Get tips, directions, distance and more with Enterprise.

Enjoy the drive through coastal cliffs, national forests and desert landscapes when you take a road trip from San Francisco to Las Vegas.

Take your time to explore this unique part of the Pacific Northwest as you make stops in Napa Valley, Crater Lake, Portland and much more.

Check out some of the top National & State Parks near San Francisco. Rent a car from one of our neighborhood locations and hit the road!

Looking to go from Los Angeles to Phoenix? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Looking to go from Los Angeles to Big Bear Lake? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Looking to go from Los Angeles to Lake Tahoe? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Looking to go from Los Angeles to Flagstaff? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Looking to go from Los Angeles to Laguna Beach? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Looking to go from Los Angeles to Las Vegas? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Are you planning a Los Angeles to Lake Tahoe road trip? Get tips, directions and more for your drive from Los Angeles to Lake Tahoe with Enterprise.

Go between the glitz and glam of LA and Vegas with this road trip. In between, you'll find nostalgic route 66 adventures, outdoor excursions, and incredible scenery to take in along the drive.

From the Mojave National Preserve to Rancho Cucamonga, make the most of your drive from Las Vegas to Disneyland with this itinerary.

Take a coastal road trip in California to Big Sur. Drive a convertible rental car to experience the best scenic views of the Golden Coast. Start a reservation.

Get ready for a beautiful vacation experience and drive to Lake Tahoe. Get more information on destinations, roads to Lake Tahoe and more with Enterprise.